Blood-Induced Joint Damage
نویسندگان
چکیده
منابع مشابه
Blood-Induced Joint Damage
Objective. Four days of blood exposure leads to irreversible cartilage damage in vitro. In contrast, intermittent intra-articular blood injections twice a week during 4 weeks (mimicking micro-bleeds) in a canine model resulted in transient damage only. In this study, it was evaluated whether acute joint bleeds are more harmful than micro-bleeds in a canine model of knee arthropathy. Design. Sev...
متن کاملHaemoglobin-derived iron-dependent hydroxyl radical formation in blood-induced joint damage: an in vitro study.
OBJECTIVE It has been reported that joint bleeds cause cartilage damage and that the combination of red blood cells (RBC) plus mononuclear cells (MNC) causes the adverse effects. The present study is to elucidate the mechanism by which blood, as present in whole blood, may cause this cartilage damage. METHODS Human cartilage samples were cultured for 4 days in the presence of 50% whole blood,...
متن کاملTHE EFFECT OF CARRAGEENAN-INDUCED INFLAMMATION ON BLOOD FLOW IN THE RABBIT KNEE JOINT
Experiments were carried out on anesthetized adult New Zealand rabbits. Acute joint inflammation was achieved by intra-articular injection of 2% carrageenan. Radiolabelled microspheres were used to measure the effect of acute inflammation on blood flow in the knee joint and establish whether neural influences on blood vessel caliber were affected. Surgical exposure of the posterior joint "capsu...
متن کاملBlood-induced joint disease: the pathophysiology of hemophilic arthropathy.
Arthropathy is a frequent and serious complication of repeated joint bleeding in patients with hemophilia, resulting in pain, deformity, and disability. Although the pathogenesis of hemophilic arthropathy has not been fully elucidated, it appears to have similarities with the degenerative joint damage that occurs in osteoarthritis and the inflammatory processes associated with rheumatoid arthri...
متن کاملEndoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood–Brain Barrier Damage
Methamphetamine (METH) abuse causes serious health problems worldwide, and long-term use of METH disrupts the blood-brain barrier (BBB). Herein, we explored the potential mechanism of endoplasmic reticulum (ER) stress in METH-induced BBB endothelial cell damage in vitro and the therapeutic potential of endoplasmic reticulum stress inhibitors for METH-induced BBB disruption in C57BL/6J mice. Exp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CARTILAGE
سال: 2013
ISSN: 1947-6035,1947-6043
DOI: 10.1177/1947603513497569